Anti-inflammatory and analgesic activities of Vatavidhvamsana rasa, An Ayurvedic herbo-mineral formulation

Background: Inflammation is a complex process mainly comprises of three phases namely acute, sub-acute and chronic. In acute inflammatory conditions fluid granulocytic cells accumulate at the site injury because changes in small blood vessels. This response often activates systemic such as leucocytosis, protein catabolism, fever synthesis C-reactive protein, an acute-phase Ayurvedic texts, several herbo-mineral preparations to fight against inflammation have been found; among them, Vatavidhvamsana Rasa (VVR) one, which said be remarkable condition. Aim Objectives: To assess anti-inflammatory analgesic effects VVR pharmacologically validated models. Materials methods: Wistar strain albino rats weighing 200 ± 20 either sex were used study. was administered dose 22.5 mg/kg for rat. Results: showed significant decrease carrageenan-induced paw oedema after 1-hour interval comparison control group (P<0.05) 3 hours 5 intervals it non-significant rats. activity, treated increase radiant heat 30 min. 60 mins initial group. Conclusion: The results concluded that has activity. Accordingly, can management pain conditions.